Which pregnancy safety category shows a proven risk of fetal harm, but still has potential benefits during pregnancy?

Category D medications are those that have shown evidence of fetal risk in human studies, but the potential benefits of the medication may still outweigh the risks under certain circumstances. This implies that there are situations where a healthcare provider may decide that the advantages of treating a pregnant patient with a Category D medication for a particular condition are significant enough that it warrants the risk of potential harm to the fetus.

In contrast, Category X medications are those that have been shown to have serious fetal risks with no acceptable use during pregnancy. Category A drugs are considered safe for use in pregnancy with no evidence of risk to the fetus. Category C medications may show some risk, but they are used when the benefits may justify the potential risks. Understanding these categories helps healthcare professionals make informed decisions concerning medication during pregnancy, balancing maternal health needs with fetal safety.